What is IgGP?

[vincentwalter]

When exporting isotypes from a cloneset I get the following isotypes:

• IgA
• IgA1
• IgA2
• IgD
• IgE
• IgG
• IgG1
• IgG2
• IgG3
• IgG4
• IgGP
• IgM

I am not aware of an isotype called IgGP and a quick google search does not produce meaningfull results.
Neither does the Janeway list such an isotype.
I searched the MiXCR docs but they do not elaborate on this topic.
Could you please explain what this means?

Thank you very much!

[mizraelson]

Hi,
IgGP stand for the non-functional IGHGP gene.

[vincentwalter]

Thank you for the quick and helpful reply. A quick follow up, though.

I got this using the cellecta-human-rna-xcr-umi-drivermap-air preset.
How can these sequences that originated from RNA and are labelled productive be based on a pseudogene?

[mizraelson]

It is hard to tell without knowing the details. To my knowledge pseudogenes can be expressed on the mRNA level in some cases.