diff --git a/packages/fluentui/CHANGELOG.md b/packages/fluentui/CHANGELOG.md
index bbd8732a1b385a..80264d7d45a7bc 100644
--- a/packages/fluentui/CHANGELOG.md
+++ b/packages/fluentui/CHANGELOG.md
@@ -23,6 +23,9 @@ This project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0.htm
 - Use shadow8 for better contrast of `Tooltip` @jurokapsiar ([#21316](https://github.com/microsoft/fluentui/pull/21316))
 - `FocusTrapZone`: add handleRef method instead of function to prevent calling it on each re-render @annabratseiko ([#21337](https://github.com/microsoft/fluentui/pull/21337))
 
+### Features
+- Add new Popup prop `closeOnScroll` to close popup when scroll happens outside of the popover element @yuanboxue-amber ([#21453](https://github.com/microsoft/fluentui/pull/21453))
+
 <!--------------------------------[ v0.60.1 ]------------------------------- -->
 ## [v0.60.1](https://github.com/microsoft/fluentui/tree/@fluentui/react-northstar_v0.60.1) (2022-01-17)
 [Compare changes](https://github.com/microsoft/fluentui/compare/@fluentui/react-northstar_v0.60.0..@fluentui/react-northstar_v0.60.1)
diff --git a/packages/fluentui/e2e/tests/popupDismissScroll-example.tsx b/packages/fluentui/e2e/tests/popupDismissScroll-example.tsx
new file mode 100644
index 00000000000000..c1fa9ef811bc27
--- /dev/null
+++ b/packages/fluentui/e2e/tests/popupDismissScroll-example.tsx
@@ -0,0 +1,52 @@
+import React from 'react';
+import { Button, Popup, Flex } from '@fluentui/react-northstar';
+
+export const selectors = {
+  simplePopup: {
+    triggerId: 'trigger',
+    contentId: 'content',
+  },
+  contextPopup: {
+    triggerId: 'trigger-context',
+    contentId: 'content-context',
+  },
+  dismissScrollPopup: {
+    triggerId: 'trigger-dismiss',
+    contentId: 'content-dismiss',
+  },
+};
+
+const PopupClickHandlingExample = () => {
+  return (
+    <Flex column>
+      simple popup
+      <Popup
+        trigger={<Button id={selectors.simplePopup.triggerId} content="Open Popup" />}
+        content={{
+          content: 'Open a popup',
+          id: selectors.simplePopup.contentId,
+        }}
+      />
+      popup open on context
+      <Popup
+        trigger={<Button id={selectors.contextPopup.triggerId} content="Open Popup" />}
+        content={{
+          content: 'Open a popup',
+          id: selectors.contextPopup.contentId,
+        }}
+        on="context"
+      />
+      popup with closeOnScroll
+      <Popup
+        trigger={<Button id={selectors.dismissScrollPopup.triggerId} content="Open Popup" />}
+        content={{
+          content: 'Open a popup',
+          id: selectors.dismissScrollPopup.contentId,
+        }}
+        closeOnScroll
+      />
+    </Flex>
+  );
+};
+
+export default PopupClickHandlingExample;
diff --git a/packages/fluentui/e2e/tests/popupDismissScroll.spec.ts b/packages/fluentui/e2e/tests/popupDismissScroll.spec.ts
new file mode 100644
index 00000000000000..a0ec61a47b634b
--- /dev/null
+++ b/packages/fluentui/e2e/tests/popupDismissScroll.spec.ts
@@ -0,0 +1,28 @@
+import { selectors } from './popupDismissScroll-example';
+
+describe('Popup - dismiss on scroll container', () => {
+  beforeEach(() => {
+    cy.gotoTestCase(__filename, `#${selectors.simplePopup.triggerId}`);
+  });
+
+  it('simple popup does not dismiss content on scroll', () => {
+    cy.clickOn(`#${selectors.simplePopup.triggerId}`); // opens popup
+    cy.visible(`#${selectors.simplePopup.contentId}`); // popup visible
+    cy.get('body').trigger('wheel'); // page scroll
+    cy.visible(`#${selectors.simplePopup.contentId}`); // popup still visible
+  });
+
+  it('popup on context dismiss content on scroll', () => {
+    cy.get(`#${selectors.contextPopup.triggerId}`).rightclick(); // opens popup
+    cy.visible(`#${selectors.contextPopup.contentId}`); // popup visible
+    cy.get('body').trigger('wheel'); // page scroll
+    cy.notExist(`#${selectors.contextPopup.contentId}`); // popup dismissed
+  });
+
+  it('popup with closeOnScroll prop dismiss content on scroll', () => {
+    cy.clickOn(`#${selectors.dismissScrollPopup.triggerId}`); // opens popup
+    cy.visible(`#${selectors.dismissScrollPopup.contentId}`); // popup visible
+    cy.get('body').trigger('wheel'); // page scroll
+    cy.notExist(`#${selectors.dismissScrollPopup.contentId}`); // popup dismissed
+  });
+});
diff --git a/packages/fluentui/react-northstar/src/components/Popup/Popup.tsx b/packages/fluentui/react-northstar/src/components/Popup/Popup.tsx
index e81f7db8a2051e..a389745e80b510 100644
--- a/packages/fluentui/react-northstar/src/components/Popup/Popup.tsx
+++ b/packages/fluentui/react-northstar/src/components/Popup/Popup.tsx
@@ -131,6 +131,9 @@ export interface PopupProps
 
   /** Controls whether or not auto focus should be applied, using boolean or AutoFocusZoneProps type value. */
   autoFocus?: boolean | AutoFocusZoneProps;
+
+  /** Close the popup when scroll happens outside of Popup */
+  closeOnScroll?: boolean;
 }
 
 export const popupClassName = 'ui-popup';
@@ -170,6 +173,7 @@ export const Popup: React.FC<PopupProps> &
     unstable_disableTether,
     unstable_pinned,
     autoSize,
+    closeOnScroll,
   } = props;
 
   const [open, setOpen] = useAutoControlled({
@@ -477,7 +481,7 @@ export const Popup: React.FC<PopupProps> &
                   capture
                 />
 
-                {isOpenedByRightClick && (
+                {(isOpenedByRightClick || closeOnScroll) && (
                   <>
                     <EventListener listener={dismissOnScroll} target={context.target} type="wheel" capture />
                     <EventListener listener={dismissOnScroll} target={context.target} type="touchmove" capture />
@@ -685,6 +689,7 @@ Popup.propTypes = {
   contentRef: customPropTypes.ref,
   trapFocus: PropTypes.oneOfType([PropTypes.bool, PropTypes.object]),
   autoFocus: PropTypes.oneOfType([PropTypes.bool, PropTypes.object]),
+  closeOnScroll: PropTypes.bool,
 };
 Popup.defaultProps = {
   accessibility: popupBehavior,