New term: Mediates association between small GTPase and other molecule (including membrane constituents) in another organism

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Preferred term label

Mediates association between a small GTPase and another molecule, including membrane constituents, in another organism.

Textual definition

This mechanism modulates host cellular signaling through direct association with a small GTPase in another organism. This is meant to distinguish factors that affect small GTPases through direct association instead of through upstream effectors. There are also parasite proteins that act as adaptors, recruiting small GTPases to certain sites on a host cell where they would not normally be found or not normally be found in large concentrations.

Examples:

• InaC from Chlaymidia trachomatis
• Ehrichia translocated factor-2 (Etf-2)
• Ehrlichia translocated factor-1 (Etf-1)
• EspW from E. coli
• CpoS from Chlamydia trachomatis
• SseF, SseG, SseJ, SteC, and SopD2 from Salmonella
• LidA, RalF, VipD from Legionella pneumophila
• RicA from Brucella
• SapM from Mycobacterium tuberculosis
• IpgD from Shigella
• YpkA from Yersinia pestis

Suggested parent term

PATHGO:0000328 (modulates host small GTPase dynamics)

Attribution

https://orcid.org/0000-0002-5702-4690