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pathgo-edit.owl
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<?xml version="1.0"?>
<rdf:RDF xmlns="http://purl.obolibrary.org/obo/PATHGO#"
xml:base="http://purl.obolibrary.org/obo/PATHGO"
xmlns:dc="http://purl.org/dc/elements/1.1/"
xmlns:obo="http://purl.obolibrary.org/obo/"
xmlns:owl="http://www.w3.org/2002/07/owl#"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:xml="http://www.w3.org/XML/1998/namespace"
xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
xmlns:skos="http://www.w3.org/2004/02/skos/core#"
xmlns:pathgo="http://purl.obolibrary.org/obo/pathgo/"
xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#">
<owl:Ontology rdf:about="http://purl.obolibrary.org/obo/PATHGO">
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathogenesis gene ontology</rdfs:comment>
<rdfs:comment>This material is licensed to the public under CC BY-NC 4.0. The U.S. Government has “Unlimited Rights” as granted and defined under FAR 52.227-14.</rdfs:comment>
<rdfs:comment>©2020 The Johns Hopkins University Applied Physics Laboratory LLC (JHU/APL). All Rights Reserved.
This material may be only be used, modified, or reproduced by or for the U.S. Government pursuant to the license rights granted under the clauses at DFARS 252.227-7013/7014 or FAR 52.227-14. For any other permission, please contact the Office of Technology Transfer at JHU/APL.
NO WARRANTY, NO LIABILITY. THIS MATERIAL IS PROVIDED “AS IS.” JHU/APL MAKES NO REPRESENTATION OR WARRANTY WITH RESPECT TO THE PERFORMANCE OF THE MATERIALS, INCLUDING THEIR SAFETY, EFFECTIVENESS, OR COMMERCIAL VIABILITY, AND DISCLAIMS ALL WARRANTIES IN THE MATERIAL, WHETHER EXPRESS OR IMPLIED, INCLUDING (BUT NOT LIMITED TO) ANY AND ALL IMPLIED WARRANTIES OF PERFORMANCE, MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, AND NON-INFRINGEMENT OF INTELLECTUAL PROPERTY OR OTHER THIRD PARTY RIGHTS. ANY USER OF THE MATERIAL ASSUMES THE ENTIRE RISK AND LIABILITY FOR USING THE MATERIAL. IN NO EVENT SHALL JHU/APL BE LIABLE TO ANY USER OF THE MATERIAL FOR ANY ACTUAL, INDIRECT, CONSEQUENTIAL, SPECIAL OR OTHER DAMAGES ARISING FROM THE USE OF, OR INABILITY TO USE, THE MATERIAL, INCLUDING, BUT NOT LIMITED TO, ANY DAMAGES FOR LOST PROFITS.</rdfs:comment>
</owl:Ontology>
<!--
///////////////////////////////////////////////////////////////////////////////////////
//
// Annotation properties
//
///////////////////////////////////////////////////////////////////////////////////////
-->
<!-- http://purl.obolibrary.org/obo/IAO_0000115 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115">
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">definition</rdfs:label>
</owl:AnnotationProperty>
<!-- http://purl.org/dc/elements/1.1/date -->
<owl:AnnotationProperty rdf:about="http://purl.org/dc/elements/1.1/date"/>
<!-- http://purl.org/dc/elements/1.1/description -->
<owl:AnnotationProperty rdf:about="http://purl.org/dc/elements/1.1/description"/>
<!-- http://www.geneontology.org/formats/oboInOwl#NamespaceIdRule -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#NamespaceIdRule">
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">namespace-id-rule</rdfs:label>
</owl:AnnotationProperty>
<!-- http://www.geneontology.org/formats/oboInOwl#auto-generated-by -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#auto-generated-by"/>
<!-- http://www.geneontology.org/formats/oboInOwl#date -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#date"/>
<!-- http://www.geneontology.org/formats/oboInOwl#default-namespace -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#default-namespace"/>
<!-- http://www.geneontology.org/formats/oboInOwl#hasDbXref -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasDbXref">
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">database_cross_reference</rdfs:label>
</owl:AnnotationProperty>
<!-- http://www.geneontology.org/formats/oboInOwl#hasOBOFormatVersion -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasOBOFormatVersion">
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">has_obo_format_version</rdfs:label>
</owl:AnnotationProperty>
<!-- http://www.geneontology.org/formats/oboInOwl#hasOBONamespace -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasOBONamespace">
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">has_obo_namespace</rdfs:label>
</owl:AnnotationProperty>
<!-- http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym">
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">has_related_synonym</rdfs:label>
</owl:AnnotationProperty>
<!-- http://www.geneontology.org/formats/oboInOwl#id -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#id"/>
<!-- http://www.geneontology.org/formats/oboInOwl#saved-by -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#saved-by"/>
<!-- http://www.w3.org/2000/01/rdf-schema#label -->
<owl:AnnotationProperty rdf:about="http://www.w3.org/2000/01/rdf-schema#label"/>
<!-- http://www.w3.org/2002/07/owl#deprecated -->
<owl:AnnotationProperty rdf:about="http://www.w3.org/2002/07/owl#deprecated"/>
<!-- http://www.w3.org/2004/02/skos/core#altLabel -->
<owl:AnnotationProperty rdf:about="http://www.w3.org/2004/02/skos/core#altLabel"/>
<!-- http://www.w3.org/2004/02/skos/core#definition -->
<owl:AnnotationProperty rdf:about="http://www.w3.org/2004/02/skos/core#definition"/>
<!-- http://www.w3.org/2004/02/skos/core#editorialNote -->
<owl:AnnotationProperty rdf:about="http://www.w3.org/2004/02/skos/core#editorialNote"/>
<!--
///////////////////////////////////////////////////////////////////////////////////////
//
// Object Properties
//
///////////////////////////////////////////////////////////////////////////////////////
-->
<!-- http://purl.obolibrary.org/obo/PATHGO_0000243 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000243">
<rdfs:subPropertyOf rdf:resource="http://www.w3.org/2002/07/owl#topObjectProperty"/>
<rdf:type rdf:resource="http://www.w3.org/2002/07/owl#InverseFunctionalProperty"/>
<rdfs:label xml:lang="en">participates_in</rdfs:label>
</owl:ObjectProperty>
<!--
///////////////////////////////////////////////////////////////////////////////////////
//
// Classes
//
///////////////////////////////////////////////////////////////////////////////////////
-->
<!-- http://purl.obolibrary.org/obo/PATHGO_0000003 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000003">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000167"/>
<obo:IAO_0000115>A mechanism that disrupts cellular transport by modulating ion channel activity in another organism.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0044069</oboInOwl:hasDbXref>
<rdfs:label>modulates ion channel activity in another organism</rdfs:label>
<skos:editorialNote>direct action on ion channel (voltage or ligand gated) or ion pump,</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000006 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000006">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000164"/>
<obo:IAO_0000115>A mechanism that disrupts cellular metabolism in another organism by modulating protein synthesis.</obo:IAO_0000115>
<rdfs:label>modulates protein synthesis in another organism</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000007 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000007">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000003"/>
<oboInOwl:hasDbXref>GO:0044762</oboInOwl:hasDbXref>
<rdfs:label>disrupts neurotransmitter release in another organism</rdfs:label>
<skos:editorialNote>example agatoxin, omega conotoxin, dendrotoxin</skos:editorialNote>
<skos:editorialNote>inconsistent as a subclass as this is a consequence of ion channel activity modulation; should be moved</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000010 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000010">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000031"/>
<rdfs:label>mediates non-specific T-cell activation in another organism</rdfs:label>
<skos:editorialNote>example SEB (superantigens)</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000016 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000016">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000333"/>
<obo:IAO_0000115>A mechanism that mediates pathogenicity by modulating immune system components and processes in another organism. Immune responses can be at the cellular level or the organismal level.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0052553</oboInOwl:hasDbXref>
<rdfs:label>modulates immune function in another organism</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000018 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000018">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000047"/>
<obo:IAO_0000115>A mechanism that disrupts exocytosis in another organism by blocking release of synaptic vesicles.</obo:IAO_0000115>
<rdfs:label>disrupts synaptic vesicle release in another organism</rdfs:label>
<skos:editorialNote>examples tetanus toxin (synaptobrevin cleavage; molecular target synaptobrevin), bot toxin (snare cleavage; molecular target snare protein)</skos:editorialNote>
<skos:editorialNote>inconsistent as a subclass as this is a specific case of disrupting exocytosis and not a mechanism by which exocytosis is disrupted</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000021 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000021">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000003"/>
<rdfs:label>disrupts post-synaptic membrane potential in other organism</rdfs:label>
<skos:editorialNote>example alpha bungarotoxin; cardiac glycosides (post syn calcium in muscle)</skos:editorialNote>
<skos:editorialNote>inconsistent as a subclass as this is a consequence of ion channel activity modulation; should be moved</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000023 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000023">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000003"/>
<oboInOwl:hasDbXref>GO:0044486</oboInOwl:hasDbXref>
<rdfs:label>disruption of action potential propagation in other organism</rdfs:label>
<skos:editorialNote>example tetrodotoxin, scorpion toxins</skos:editorialNote>
<skos:editorialNote>inconsistent as a subclass as this is a consequence of ion channel activity modulation; should be moved</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000025 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000025">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000316"/>
<obo:IAO_0000115>A mechanism that modulates eukaryotic translation elongation factors in another organism by activating eukaryotic translation elongation factors.</obo:IAO_0000115>
<rdfs:label>activates translation elongation factors in another organism</rdfs:label>
<skos:editorialNote>https://orcid.org/0000-0002-5702-4690</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000028 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000028">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000166"/>
<obo:IAO_0000115>A mechanism that modulates cytoskeleton dynamics in another organism by altering maintenance of cytoskeleton.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0052039</oboInOwl:hasDbXref>
<rdfs:label>modulates cytoskeleton dynamics in another organism</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000029 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000029">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000166"/>
<obo:IAO_0000115>A mechanism that disrupts cellular structure of another organism by damaging the cell membrane.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0051673</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref>GO:0052025</oboInOwl:hasDbXref>
<oboInOwl:hasRelatedSynonym>lysis of host cells</oboInOwl:hasRelatedSynonym>
<rdfs:label>mediates membrane damage of another organism</rdfs:label>
<skos:editorialNote>consider vacuolization</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000030 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000030">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000006"/>
<obo:IAO_0000115>A mechanism that modulates protein synthesis in another organism by ribosome inactivation.</obo:IAO_0000115>
<rdfs:label>mediates ribosome inactivation in another organism</rdfs:label>
<skos:editorialNote>For example, Ricin toxin.</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000031 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000031">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000016"/>
<rdfs:label>mediates non-productive immune system activation in another organism</rdfs:label>
<skos:editorialNote>evaluate class name and intent; determine how to capture superantigens
Evaluate changing label to "mediates immune system activation"</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000033 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000033">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000029"/>
<obo:IAO_0000115>A mechanism that mediates membrane damage by formation of pores in another organism.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0035915</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref>GO:0044658</oboInOwl:hasDbXref>
<rdfs:label>mediates pore formation in another organism</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000038 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000038">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000147"/>
<obo:IAO_0000115>A mechanism that enables adhesion by mediating attachment to cells of the host they are infecting or living in.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0044406</oboInOwl:hasDbXref>
<oboInOwl:hasRelatedSynonym>adhesin</oboInOwl:hasRelatedSynonym>
<rdfs:label>mediates adhesion in another organism</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000040 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000040">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000333"/>
<obo:IAO_0000115>A mechanism that mediates pathogenicity by disrupting the plasma membrane potential of cells in another organism.</obo:IAO_0000115>
<rdfs:label>disrupts membrane potential in another organism</rdfs:label>
<skos:editorialNote>Does this fit better anywhere else?</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000047 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000047">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000167"/>
<obo:IAO_0000115>A mechanism that disrupts cellular transport in another organism by blocking exocytosis.</obo:IAO_0000115>
<rdfs:label>disrupts exocytosis in another organism</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000055 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000055">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000029"/>
<obo:IAO_0000115>A mechanism that mediates membrane damage in another organism by cleavage of membrane phospholipids.</obo:IAO_0000115>
<rdfs:label>mediates membrane phospholipid cleavage in another organism</rdfs:label>
<skos:editorialNote>evaluate for placement in invasion and dissemination</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000058 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000058">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000113"/>
<obo:IAO_0000115>A mechanism of nutrient availability or uptake that involves acquisition of iron.</obo:IAO_0000115>
<rdfs:label>mediates iron acquisition</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000062 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000062">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000147"/>
<obo:IAO_0000115>A mechanism that enables adhesion by promoting synthesis of extracellular polymeric substances to form a biofilm.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:1900190</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref>GO:1900230</oboInOwl:hasDbXref>
<rdfs:label>mediates biofilm formation</rdfs:label>
<skos:editorialNote>Process whereby microorganisms irreversibly attach to and grow on a surface and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription. (Donlan, Rodney M. "Biofilm formation: a clinically relevant microbiological process." Clinical Infectious Diseases 33.8 (2001): 1387-1392.)
Mechanism of colonization that involves synthesis of extracellular polymeric substances in a film.</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000066 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000066">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000058"/>
<obo:IAO_0000115>A mechanism of iron acquisition that involves taking iron from a target cell.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0044847</oboInOwl:hasDbXref>
<rdfs:label>mediates iron acquisition from host</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000069 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000069">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000099"/>
<obo:IAO_0000115>A mechanism that mediates extracellular matrix binding in another organism by binding to collagen.</obo:IAO_0000115>
<rdfs:label>mediates collagen binding in another organism</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000072 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000072">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000211"/>
<obo:IAO_0000115>A mechanism that mediates cell surface binding of another organism by binding to glycoproteins (i.e. sugar-modified proteins) on the surface of a cell</obo:IAO_0000115>
<rdfs:label>mediates surface glycoprotein binding of another organism</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000074 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000074">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000251"/>
<obo:IAO_0000115>A mechanism that mediates dissemination in another organism by stimulation of host blood vessel generation, or angiogenesis.</obo:IAO_0000115>
<rdfs:label>mediates induction of angiogenesis in another organism</rdfs:label>
<skos:editorialNote>example Bartonella BafA
evaluate proangiogenic response as a contribution to pathogenesis</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000080 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000080">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000085"/>
<obo:IAO_0000115>A mechanism that mediates immune evasion and subversion in another organism by blocking immature dendritic immune cells from maturing into antigen-presenting, T cell activating cells.</obo:IAO_0000115>
<rdfs:label>suppresses dendritic cell maturation in another organism</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000084 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000084">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000085"/>
<obo:IAO_0000115>A mechanism that mediates immune evasion and subversion in another organism by preventing lymphocytes from growing via cell division.</obo:IAO_0000115>
<rdfs:label>inhibits lymphocyte proliferation in another organism</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000085 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000085">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000016"/>
<obo:IAO_0000115>A mechanism that mediates pathogenicity by modulating the availability or function of immune system components in another organism, to evade or subvert host immune functions.</obo:IAO_0000115>
<rdfs:label>mediates immune evasion and subversion in another organism</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000089 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000089">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000164"/>
<obo:IAO_0000115>A mechanism that disrupts cellular metabolism in another organism by disrupting the mitochondrial membrane potential.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0033659</oboInOwl:hasDbXref>
<rdfs:label>disrupts mitochondrial membrane potential in another organism</rdfs:label>
<skos:editorialNote>For example, during infection Listeria monocytogenes induces a loss of mitochondrial membrane potential by expressing listeriolysin O (LLO) which causes mitochondrial fission. This change leads to reduced ATP production.</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000099 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000099">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000038"/>
<obo:IAO_0000115>A mechanism that enables adhesion in another organism by mediating binding to extracellular matrix components such as collagen and fibronectin.</obo:IAO_0000115>
<rdfs:label>mediates extracellular matrix binding in another organism</rdfs:label>
<skos:editorialNote>Mechanism of adherence in which attachment occurs to components of the extracellular matrix as opposed to the target cell directly;
elaborate subclasses
Collagen binding protein and fibronectin binding protein are examples. Including these as subclasses may be too granular.</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000100 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000100">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000085"/>
<obo:IAO_0000115>A mechanism that mediates immune evasion and subversion in another organism by countering the effects of the complement system, a component of the innate immune system.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0042784</oboInOwl:hasDbXref>
<rdfs:label>mediates resistance to complement system in another organism</rdfs:label>
<skos:editorialNote>resistance to complement-mediated killing
example:component 1 (C1) protease</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000104 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000104">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000085"/>
<obo:IAO_0000115>A mechanism that mediates immune evasion and subversion in another organism by preventing antibacterial peptides from binding to their targets.</obo:IAO_0000115>
<rdfs:label>disrupts antimicrobial peptide binding in another organism</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000108 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000108">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000028"/>
<obo:IAO_0000115>A mechanism that modulates the cytoskeleton in cells of another organism by mediating inhibition of actin polymerization.</obo:IAO_0000115>
<rdfs:label>mediates actin polymerization inhibition in another organism</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000110 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000110">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000336"/>
<obo:IAO_0000115>A mechanism that mediates pathogenicity indirectly by contributing to secretion of protein effectors from the pathogen into the extracellular environment or directly into the host cell.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0042000</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref>GO:0044417</oboInOwl:hasDbXref>
<rdfs:label>mediates secretion of protein effectors</rdfs:label>
<skos:editorialNote>elaborate subclasses and align with determinant branch
The secretion pathways are typically described as "types" based on components/structures involved corresponding to variations on a few general strategies involving transport across inner membrane, transport across inner membrane followed by transport across outer membrane (two-step), transport across both membranes. Several types can also transport proteins directly across the host cell membrane to deliver effectors directly into cells
Type I- one step to extracellular
Type II- two step, first step is independent transport into periplasm
Type III- spans both membranes, injectosome into host cell
Type IV- spans both membranes, release of effectors into other cell (conjugation)
Type V-autotransporter in OM, first step is independent transport into periplasm
Type VI- spans both membranes, release into other cell
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804464/
https://www.sciencedirect.com/science/article/pii/S0167488904000783
Evaluate subclass naming/organization</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000113 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000113">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000150"/>
<obo:IAO_0000115>A mechanism that promotes survival in host by contributing to the availability and/or uptake of nutrients from host cells or the environment.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0044002</oboInOwl:hasDbXref>
<rdfs:label>mediates nutrient acquisition</rdfs:label>
<skos:editorialNote>evaluate and modify subclasses to achieve consistent structure
examples may include: gelatinase, mucinase, sialidase, hyaluronidase - enzymes that are also associated with destruction of extracellular matrix, mucus, etc. to promote invasion and spread in the host
siderophore-chelate and sequester iron from host</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000114 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000114">
<obo:IAO_0000115>A mechanism of pathogenicity is a means by which a damaging effect is brought about, and that specifically describes how that effect is exerted.</obo:IAO_0000115>
<rdfs:label>mechanism of pathogenicity</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000124 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000124">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000058"/>
<obo:IAO_0000115>A mechanism of iron acquisition that involves using iron in the environment.</obo:IAO_0000115>
<rdfs:label>mediates iron acquisition from environment</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000132 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000132">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000164"/>
<obo:IAO_0000115>A mechanism that disrupts cellular metabolism in another organism by inhibiting DNA synthesis.</obo:IAO_0000115>
<rdfs:label>mediates DNA synthesis inhibition in another organism</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000133 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000133">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000099"/>
<obo:IAO_0000115>A mechanism that mediates extracellular matrix binding in another organism by binding to fibronectin.</obo:IAO_0000115>
<rdfs:label>mediates fibronectin binding in another organism</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000142 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000142">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000113"/>
<obo:IAO_0000115>A mechanism that mediates nutrient acquisition by taking cholesterol from the membranes of target cells.</obo:IAO_0000115>
<rdfs:label>mediates acquisition of cholesterol from membrane</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000147 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000147">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000336"/>
<obo:IAO_0000115>A mechanism that mediates pathogenicity indirectly by enabling pathogens to attach to substrates and/or cells of another organism to establish growth.</obo:IAO_0000115>
<oboInOwl:hasDbXref>BVF:0000002</oboInOwl:hasDbXref>
<rdfs:label>enables adhesion</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000150 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000150">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000336"/>
<obo:IAO_0000115>A mechanism that mediates pathogenicity indirectly by promoting survival in the host, especially when environmental conditions are unfavorable, distinct from adherence and colonization.</obo:IAO_0000115>
<rdfs:label>promotes survival in host</rdfs:label>
<skos:editorialNote>evaluate placement and provide examples</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000152 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000152">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000331"/>
<obo:IAO_0000115>A mechanism that modulates the cell cycle in cells of another organism by inducing cell cycle arrest.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0044072</oboInOwl:hasDbXref>
<rdfs:label>induces cell cycle arrest in cells of another organism</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000154 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000154">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000113"/>
<obo:IAO_0000115>A mechanism of nutrient availability or uptake that involves acquisition of manganese.</obo:IAO_0000115>
<rdfs:label>mediates manganese acquisition</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000159 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000159">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000357"/>
<obo:IAO_0000115>A mechanism that mediates pathogenicity by disrupting the adhesion of cells to other cells and/or extracellular matrix components in another organism.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0044067</oboInOwl:hasDbXref>
<rdfs:label>disrupts cell-cell adhesion in another organism</rdfs:label>
<skos:editorialNote>evaluate for incorporation to invasion and dissemination
elaborate subclasses</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000161 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000161">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000357"/>
<obo:IAO_0000115>A mechanism that disrupts tissue structure by damaging the mucosal barrier in another organism, permitting microbial products and/or microbes entry into that organism. The intestinal mucosal barrier consists of the intestinal epithelial layer, plus additional physical, biochemical, and immunological components.</obo:IAO_0000115>
<oboInOwl:hasRelatedSynonym>gastrointestinal barrier disruption</oboInOwl:hasRelatedSynonym>
<rdfs:label>disrupts mucosal barrier in another organism</rdfs:label>
<skos:editorialNote>higher level process, not appropriate subclass; evaluate for removal or alternate placement; revise definition</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000162 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000162">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000357"/>
<obo:IAO_0000115>A mechanism that compromises epithelial cell layers in another organism, enabling increased permeation of biomolecules and/or bacterial invasion.</obo:IAO_0000115>
<rdfs:label>disrupts epithelial layers in another organism</rdfs:label>
<skos:editorialNote>higher level process, not appropriate subclass; evaluate for removal or alternate placement</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000164 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000164">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000333"/>
<obo:IAO_0000115>A mechanism that mediates pathogenicity by disrupting cellular processes involved in the synthesis or breakdown of cellular constituents or production of energy in another organism.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0044068</oboInOwl:hasDbXref>
<rdfs:label>disrupts cellular metabolism in another organism</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000165 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000165">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000333"/>
<obo:IAO_0000115>A mechanism that mediates pathogenicity by disrupting cellular signaling processes in another organism.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0044501</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref>GO:0052027</oboInOwl:hasDbXref>
<rdfs:label>disrupts cellular signaling in another organism</rdfs:label>
<skos:editorialNote>refine/build out subclasses</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000166 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000166">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000333"/>
<obo:IAO_0000115>A mechanism that mediates pathogenicity by disrupting the structural integrity of a cell in another organism.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0052111</oboInOwl:hasDbXref>
<rdfs:label>disrupts cellular structure in another organism</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000167 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000167">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000333"/>
<obo:IAO_0000115>A mechanism that mediates pathogenicity by disrupting transport of products into, out of, and within cells in another organism.</obo:IAO_0000115>
<rdfs:label>disrupts cellular transport in another organism</rdfs:label>
<skos:editorialNote>elaborate and restructure subclasses using a consistent organizational principle
example concepts to consider in determining organization:
membrane transport
vesicular transport
endocytosis/exocytosis
active/passive
intracellular trafficking
microtubule mediated transport</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000170 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000170">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000164"/>
<obo:IAO_0000115>A mechanism that disrupts cellular metabolism by altering the levels of cyclic adenosine monophosphate (cyclic AMP, or cAMP) in cells of another organism. Cyclic AMP is a second messenger molecule that regulates physiological processes in cells, through, for example, activation of intracellular signaling pathways.</obo:IAO_0000115>
<rdfs:label>disrupts cAMP levels within cells of another organism</rdfs:label>
<skos:editorialNote>redundant to cellular signaling "second messenger disruption"; should be moved; evaluate subclasses</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000172 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000172">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000353"/>
<obo:IAO_0000115>A mechanism that modulates reactive oxygen species levels in another organism by enhancing nitric oxide radical production, through activation of nitric oxide synthase or otherwise.</obo:IAO_0000115>
<rdfs:label>enhances nitric oxide radical production in another organism</rdfs:label>
<skos:editorialNote>Nitric oxide radicals destroy iron-dependent enzymes, eventually inhibiting mitochondrial function and DNA synthesis in host cells.
evaluate placement; not appropriate subclass</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000173 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000173">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000170"/>
<obo:IAO_0000115>A mechanism that disrupts cellular cAMP levels within cells of another organism through activation of the production or repression of the breakdown of cAMP.</obo:IAO_0000115>
<rdfs:label>modulates cAMP synthesis within cells of another organism</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000174 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000174">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000170"/>
<obo:IAO_0000115>A mechanism that disrupts cellular cAMP levels within cells of another organism through regulation of adenylate cyclases or phosphodiesterases.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0043963</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref>GO:0075106</oboInOwl:hasDbXref>
<rdfs:label>regulates adenylate cyclases/phosphodiesterases in another organism</rdfs:label>
<skos:editorialNote>evaluate for redundancy with "modulates cAMP synthesis"</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000175 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000175">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000165"/>
<obo:IAO_0000115>A mechanism that disrupts cellular signaling in another organism by modulating G-protein signaling pathways.</obo:IAO_0000115>
<rdfs:label>modulates G-protein signaling pathways in another organism</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000176 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000176">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000165"/>
<obo:IAO_0000115>A mechanism that disrupts cellular signaling in another organism by modulating receptor activity.</obo:IAO_0000115>
<rdfs:label>modulates receptor activity in another organism</rdfs:label>
<skos:editorialNote>In most cases, this term will be used to reflect interactions with cell surface receptors, such as with eukaryotic toxins or bacterial proteins like superantigens. However, the term is broad enough that it could also capture effects on intracellular receptors, such as ER localized receptors.</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000211 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000211">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000038"/>
<obo:IAO_0000115>A mechanism that mediates adhesion by enabling binding to cell surface receptors or components of another organism.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0044650</oboInOwl:hasDbXref>
<rdfs:label xml:lang="en">mediates binding to the cell surface of another organism</rdfs:label>
<skos:editorialNote>elaborate subclasses
sialyl Lewis x binding protein is an example</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000213 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000213">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000159"/>
<obo:IAO_0000115>A mechanism that disrupts cell-cell adhesion in another organism by suppressing platelet aggregation.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0035893</oboInOwl:hasDbXref>
<rdfs:label xml:lang="en">suppresses platelet aggregation in another organism</rdfs:label>
<skos:editorialNote>for example: coagulation factor V protease, or disintegrins
not an appropriate subclass as this is a specific example, evaluate for class related to inhibition of integrin mediated adhesion "disrupts "integrin-dependent adhesion"
also, consider combining with "disrupts coagulation in another organism" branch.</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000214 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000214">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000159"/>
<obo:IAO_0000115>A mechanism that disrupts cell-cell adhesion in another organism by modifying cellular junctional complexes, including tight junctions and/or adherens junctions.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0098864</oboInOwl:hasDbXref>
<rdfs:label xml:lang="en">modifies host tight or adherens junctions in another organism</rdfs:label>
<skos:editorialNote>example: Clostridium perfringens type A toxin (targets claudins) more info: https://doi.org/10.1016/j.bbamem.2008.10.028; https://www.ncbi.nlm.nih.gov/pubmed/11595640
Term changes suggested by Gene Godbold (https://orcid.org/0000-0002-5702-4690)</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000215 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000215">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000164"/>
<obo:IAO_0000115>A mechanism that disrupts cellular metabolism by suppressing metabolic enzymes in another organism.</obo:IAO_0000115>
<rdfs:label xml:lang="en">suppresses metabolic enzymes in another organism</rdfs:label>
<skos:editorialNote>Provide examples, or consider for removal. Is metabolic enzyme suppression specifically a common mechanism of pathogenesis?</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000216 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000216">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000028"/>
<obo:IAO_0000115>A mechanism that modulates the cytoskeleton in cells of another organism by mediating actin depolymerization.</obo:IAO_0000115>
<rdfs:label xml:lang="en">mediates actin depolymerization in another organism</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000217 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000217">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000028"/>
<obo:IAO_0000115>A mechanism that modulates the cytoskeleton in cells of another organism by promoting actin crosslinking.</obo:IAO_0000115>
<rdfs:label xml:lang="en">mediates actin crosslinking in another organism</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000220 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000220">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000085"/>
<obo:IAO_0000115>A mechanism that mediates immune evasion and subversion in another organism by suppressing release of inflammatory cytokines.</obo:IAO_0000115>
<rdfs:label xml:lang="en">suppresses inflammatory cytokine release in another organism</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000221 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000221">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000028"/>
<obo:IAO_0000115>A mechanism that modulates the cytoskeleton in cells of another organism by mediating microtubule stabilization.</obo:IAO_0000115>
<rdfs:label xml:lang="en">mediates microtubule stabilization in another organism</rdfs:label>
<skos:editorialNote>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625037/</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000222 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000222">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000028"/>
<obo:IAO_0000115>A mechanism that modulates the cytoskeleton in cells of another organism by mediating microtubule destabilization.</obo:IAO_0000115>
<rdfs:label xml:lang="en">mediates microtubule destabilization in another organism</rdfs:label>
<skos:editorialNote>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625037/</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000225 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000225">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000038"/>
<obo:IAO_0000115>A mechanism that mediates adhesion in another organism by contributing to the formation of an adhesion appendage.</obo:IAO_0000115>
<rdfs:label xml:lang="en">contributes to adhesion appendage formation</rdfs:label>
<skos:editorialNote>Fimbriae proteins/subunits are examples.
Intended to capture components that are not directly adhesins, but this class may not be structurally consistent.
No term in GO for describing "scaffolding" of a adhesion molecule.
Candidate for removal as the effect here is very indirect.</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000226 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000226">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000357"/>
<obo:IAO_0000115>A mechanism that mediates pathogenicity by disrupting extracellular matrix components in another organism.</obo:IAO_0000115>
<rdfs:label xml:lang="en">disrupts extracellular matrix in another organism</rdfs:label>
<skos:editorialNote>gelatinase, mucinase, sialidase, hyaluronidase, etc.</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000230 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000230">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000085"/>
<obo:IAO_0000115>A mechanism that mediates immune evasion and subversion by detoxifying free radicals in another organism.</obo:IAO_0000115>
<rdfs:label xml:lang="en">mediates free radical detoxification in another organism</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000231 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000231">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000232"/>
<obo:IAO_0000115>A mechanism that suppresses phagocytosis by suppressing opsonization, the process by which particles are targeted for phagocytosis.</obo:IAO_0000115>
<rdfs:label xml:lang="en">suppresses opsonization in another organism</rdfs:label>
<skos:editorialNote>If a mechanism inhibits opsonization, which is the process of marking foreign particles for phagocytosis by marking them with opsonins, then it necessarily also inhibits phagocytosis.</skos:editorialNote>
</owl:Class>