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pathgo.owl
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<?xml version="1.0"?>
<rdf:RDF xmlns="http://purl.obolibrary.org/obo/PATHGO#"
xml:base="http://purl.obolibrary.org/obo/PATHGO"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:owl="http://www.w3.org/2002/07/owl#"
xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
xmlns:xml="http://www.w3.org/XML/1998/namespace"
xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
xmlns:skos="http://www.w3.org/2004/02/skos/core#"
xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
xmlns:obo="http://purl.obolibrary.org/obo/"
xmlns:dc="http://purl.org/dc/elements/1.1/">
<owl:Ontology rdf:about="http://purl.obolibrary.org/obo/PATHGO">
<owl:versionIRI rdf:resource="http://purl.obolibrary.org/obo/pathgo/releases/2021-03-22/pathgo.owl"/>
<rdfs:comment>©2020 The Johns Hopkins University Applied Physics Laboratory LLC (JHU/APL). All Rights Reserved.
This material may be only be used, modified, or reproduced by or for the U.S. Government pursuant to the license rights granted under the clauses at DFARS 252.227-7013/7014 or FAR 52.227-14. For any other permission, please contact the Office of Technology Transfer at JHU/APL.
NO WARRANTY, NO LIABILITY. THIS MATERIAL IS PROVIDED “AS IS.” JHU/APL MAKES NO REPRESENTATION OR WARRANTY WITH RESPECT TO THE PERFORMANCE OF THE MATERIALS, INCLUDING THEIR SAFETY, EFFECTIVENESS, OR COMMERCIAL VIABILITY, AND DISCLAIMS ALL WARRANTIES IN THE MATERIAL, WHETHER EXPRESS OR IMPLIED, INCLUDING (BUT NOT LIMITED TO) ANY AND ALL IMPLIED WARRANTIES OF PERFORMANCE, MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, AND NON-INFRINGEMENT OF INTELLECTUAL PROPERTY OR OTHER THIRD PARTY RIGHTS. ANY USER OF THE MATERIAL ASSUMES THE ENTIRE RISK AND LIABILITY FOR USING THE MATERIAL. IN NO EVENT SHALL JHU/APL BE LIABLE TO ANY USER OF THE MATERIAL FOR ANY ACTUAL, INDIRECT, CONSEQUENTIAL, SPECIAL OR OTHER DAMAGES ARISING FROM THE USE OF, OR INABILITY TO USE, THE MATERIAL, INCLUDING, BUT NOT LIMITED TO, ANY DAMAGES FOR LOST PROFITS.</rdfs:comment>
<rdfs:comment>This material is licensed to the public under CC BY-NC 4.0. The U.S. Government has “Unlimited Rights” as granted and defined under FAR 52.227-14.</rdfs:comment>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathogenesis gene ontology</rdfs:comment>
</owl:Ontology>
<!--
///////////////////////////////////////////////////////////////////////////////////////
//
// Annotation properties
//
///////////////////////////////////////////////////////////////////////////////////////
-->
<!-- http://purl.obolibrary.org/obo/IAO_0000115 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115">
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">definition</rdfs:label>
</owl:AnnotationProperty>
<!-- http://purl.org/dc/elements/1.1/date -->
<owl:AnnotationProperty rdf:about="http://purl.org/dc/elements/1.1/date"/>
<!-- http://purl.org/dc/elements/1.1/description -->
<owl:AnnotationProperty rdf:about="http://purl.org/dc/elements/1.1/description"/>
<!-- http://www.geneontology.org/formats/oboInOwl#NamespaceIdRule -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#NamespaceIdRule">
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">namespace-id-rule</rdfs:label>
</owl:AnnotationProperty>
<!-- http://www.geneontology.org/formats/oboInOwl#auto-generated-by -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#auto-generated-by"/>
<!-- http://www.geneontology.org/formats/oboInOwl#date -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#date"/>
<!-- http://www.geneontology.org/formats/oboInOwl#default-namespace -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#default-namespace"/>
<!-- http://www.geneontology.org/formats/oboInOwl#hasDbXref -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasDbXref">
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">database_cross_reference</rdfs:label>
</owl:AnnotationProperty>
<!-- http://www.geneontology.org/formats/oboInOwl#hasOBOFormatVersion -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasOBOFormatVersion">
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">has_obo_format_version</rdfs:label>
</owl:AnnotationProperty>
<!-- http://www.geneontology.org/formats/oboInOwl#hasOBONamespace -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasOBONamespace">
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">has_obo_namespace</rdfs:label>
</owl:AnnotationProperty>
<!-- http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym">
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">has_related_synonym</rdfs:label>
</owl:AnnotationProperty>
<!-- http://www.geneontology.org/formats/oboInOwl#id -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#id"/>
<!-- http://www.geneontology.org/formats/oboInOwl#saved-by -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#saved-by"/>
<!-- http://www.w3.org/2000/01/rdf-schema#label -->
<owl:AnnotationProperty rdf:about="http://www.w3.org/2000/01/rdf-schema#label"/>
<!-- http://www.w3.org/2002/07/owl#deprecated -->
<owl:AnnotationProperty rdf:about="http://www.w3.org/2002/07/owl#deprecated"/>
<!-- http://www.w3.org/2004/02/skos/core#altLabel -->
<owl:AnnotationProperty rdf:about="http://www.w3.org/2004/02/skos/core#altLabel"/>
<!-- http://www.w3.org/2004/02/skos/core#definition -->
<owl:AnnotationProperty rdf:about="http://www.w3.org/2004/02/skos/core#definition"/>
<!-- http://www.w3.org/2004/02/skos/core#editorialNote -->
<owl:AnnotationProperty rdf:about="http://www.w3.org/2004/02/skos/core#editorialNote"/>
<!--
///////////////////////////////////////////////////////////////////////////////////////
//
// Object Properties
//
///////////////////////////////////////////////////////////////////////////////////////
-->
<!-- http://purl.obolibrary.org/obo/PATHGO_0000243 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000243">
<rdfs:subPropertyOf rdf:resource="http://www.w3.org/2002/07/owl#topObjectProperty"/>
<rdf:type rdf:resource="http://www.w3.org/2002/07/owl#InverseFunctionalProperty"/>
<rdfs:label xml:lang="en">participates_in</rdfs:label>
</owl:ObjectProperty>
<!--
///////////////////////////////////////////////////////////////////////////////////////
//
// Classes
//
///////////////////////////////////////////////////////////////////////////////////////
-->
<!-- http://purl.obolibrary.org/obo/PATHGO_0000003 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000003">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000167"/>
<obo:IAO_0000115>A mechanism that disrupts cellular transport by modulating ion channel activity.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0044069</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref>GO:0099106</oboInOwl:hasDbXref>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">modulates ion channel activity</rdfs:label>
<skos:editorialNote rdf:datatype="http://www.w3.org/2001/XMLSchema#string">direct action on ion channel (voltage or ligand gated) or ion pump,</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000006 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000006">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000164"/>
<obo:IAO_0000115>A mechanism that disrupts cellular metabolism by modulating protein synthesis.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0044074</oboInOwl:hasDbXref>
<rdfs:label>modulates protein synthesis</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000007 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000007">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000003"/>
<oboInOwl:hasDbXref>GO:0044762</oboInOwl:hasDbXref>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">disruption of neurotransmitter release</rdfs:label>
<skos:editorialNote rdf:datatype="http://www.w3.org/2001/XMLSchema#string">example agatoxin, omega conotoxin, dendrotoxin</skos:editorialNote>
<skos:editorialNote>inconsistent as a subclass as this is a consequence of ion channel activity modulation; should be moved</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000010 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000010">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000031"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">mediates non-specific T-cell activation</rdfs:label>
<skos:editorialNote rdf:datatype="http://www.w3.org/2001/XMLSchema#string">example SEB (superantigens)</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000016 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000016">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000114"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mechanism that mediates pathogenicity by modulating host immune system components and processes. Immune responses can be at the cellular level, or the organismal level.</obo:IAO_0000115>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">modulates host immune function</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000018 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000018">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000047"/>
<obo:IAO_0000115>A mechanism that prevents exocytosis by blocking release of synaptic vesicles.</obo:IAO_0000115>
<rdfs:label>disrupts synaptic vesicle release</rdfs:label>
<skos:editorialNote rdf:datatype="http://www.w3.org/2001/XMLSchema#string">examples tetanus toxin (synaptobrevin cleavage; molecular target synaptobrevin), bot toxin (snare cleavage; molecular target snare protein)</skos:editorialNote>
<skos:editorialNote>inconsistent as a subclass as this is a specific case of disrupting exocytosis and not a mechanism by which exocytosis is disrupted</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000021 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000021">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000003"/>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">disruption of post-synaptic membrane potential</rdfs:label>
<skos:editorialNote rdf:datatype="http://www.w3.org/2001/XMLSchema#string">example alpha bungarotoxin; cardiac glycosides (post syn calcium in muscle)</skos:editorialNote>
<skos:editorialNote>inconsistent as a subclass as this is a consequence of ion channel activity modulation; should be moved</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000023 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000023">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000003"/>
<oboInOwl:hasDbXref>GO:0044486</oboInOwl:hasDbXref>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">disruption of action potential propagation</rdfs:label>
<skos:editorialNote rdf:datatype="http://www.w3.org/2001/XMLSchema#string">example tetrodotoxin, scorpion toxins</skos:editorialNote>
<skos:editorialNote>inconsistent as a subclass as this is a consequence of ion channel activity modulation; should be moved</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000025 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000025">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000316"/>
<obo:IAO_0000115>A mechanism that modulates eukaryotic translation elongation factors by activating eukaryotic translation elongation factors.</obo:IAO_0000115>
<rdfs:label>activates translation elongation factors</rdfs:label>
<skos:editorialNote>https://orcid.org/0000-0002-5702-4690</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000028 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000028">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000166"/>
<obo:IAO_0000115>A mechanism that modulates cytoskeleton in host cell by altering maintenance of cytoskeleton.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0052039</oboInOwl:hasDbXref>
<rdfs:label>modulates cytoskeleton in host cell</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000029 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000029">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000166"/>
<obo:IAO_0000115>A mechanism that disrupts cellular structure by damaging the cell membrane.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0051673</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref>GO:0052025</oboInOwl:hasDbXref>
<oboInOwl:hasRelatedSynonym>lysis of host cells</oboInOwl:hasRelatedSynonym>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">mediates membrane damage</rdfs:label>
<skos:editorialNote>consider vacuolization</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000030 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000030">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000006"/>
<obo:IAO_0000115>A mechanism that modulates protein synthesis by ribosome inactivation.</obo:IAO_0000115>
<rdfs:label>mediates ribosome inactivation</rdfs:label>
<skos:editorialNote rdf:datatype="http://www.w3.org/2001/XMLSchema#string">For example, Ricin toxin.</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000031 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000031">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000016"/>
<rdfs:label>mediates non-productive immune system activation</rdfs:label>
<skos:editorialNote>evaluate class name and intent; determine how to capture superantigens
Evaluate changing label to "mediates immune system activation"</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000033 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000033">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000029"/>
<obo:IAO_0000115>A mechanism that mediates membrane damage by formation of pores.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0044658</oboInOwl:hasDbXref>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">mediates pore formation</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000038 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000038">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000147"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mechanism that enables adhesion and colonization by mediating attachment to cells or to surfaces, usually the host they are infecting or living in.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0044406</oboInOwl:hasDbXref>
<oboInOwl:hasRelatedSynonym>adhesin</oboInOwl:hasRelatedSynonym>
<rdfs:label>mediates adhesion</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000040 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000040">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000114"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mechanism that mediates pathogenicity by disrupting the plasma membrane potential of host cells.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0042391</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref>GO:0044662</oboInOwl:hasDbXref>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">disrupts membrane potential</rdfs:label>
<skos:editorialNote>Does this fit better anywhere else?</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000047 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000047">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000167"/>
<obo:IAO_0000115>A mechanism that disrupts cellular transport by blocking exocytosis.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0045920</oboInOwl:hasDbXref>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">disrupts exocytosis</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000055 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000055">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000029"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mechanism that mediates membrane damage by cleavage of membrane phospholipids.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0009395</oboInOwl:hasDbXref>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">mediates membrane phospholipid cleavage</rdfs:label>
<skos:editorialNote>evaluate for placement in invasion and dissemination</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000058 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000058">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000113"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mechanism of nutrient avialability or uptake that involves acquisition of iron.</obo:IAO_0000115>
<rdfs:label>mediates iron uptake</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000062 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000062">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000147"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mechanism that enables adhesion and colonization by promoting synthesis of extracellular polymeric substances to form a biofilm.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:1900190</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref>GO:1900230</oboInOwl:hasDbXref>
<rdfs:label>mediates biofilm formation</rdfs:label>
<skos:editorialNote rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Process whereby microorganisms irreversibly attach to and grow on a surface and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription. (Donlan, Rodney M. "Biofilm formation: a clinically relevant microbiological process." Clinical Infectious Diseases 33.8 (2001): 1387-1392.)
Mechanism of colonization that involves synthesis of extracellular polymeric substances in a film.</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000066 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000066">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000058"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mechanism of iron uptake that involves taking iron from a target cell.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0044847</oboInOwl:hasDbXref>
<rdfs:label>mediates iron acquisition from host</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000069 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000069">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000099"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mechanism that mediates extracellular matrix binding by binding to collagen.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0005518</oboInOwl:hasDbXref>
<rdfs:label>mediates host collagen binding</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000072 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000072">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000211"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mechanism that mediates cell surface binding by binding to glycoproteins (i.e. sugar-modified proteins) on the surface of a cell</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0140081</oboInOwl:hasDbXref>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">mediates surface glycoprotein binding</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000074 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000074">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000150"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mechanism that mediates proliferation and survival by stimulation of host blood vessel generation, or angiogenesis.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0045766</oboInOwl:hasDbXref>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">mediates induction of angiogenesis</rdfs:label>
<skos:editorialNote>example VEGF
evaluate proangiogenic response as a contribution to pathogenesis</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000080 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000080">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000085"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mechanism that mediates immune evasion and subversion by blocking immature dendritic immune cells from maturing into antigen-presenting, T cell activating cells.</obo:IAO_0000115>
<rdfs:label>inhibits dendritic cell maturation</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000082 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000082">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000113"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mechanism of nutrient availability or uptake that involves peptide and protein degradation.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0052014</oboInOwl:hasDbXref>
<rdfs:label>mediates peptide and protein degradation</rdfs:label>
<skos:editorialNote>overlaps with extracellular matrix destruction under invasion and dissemination</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000084 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000084">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000085"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mechanism that mediates immune evasion and subversion by preventing lymphocytes from growing via cell division.</obo:IAO_0000115>
<rdfs:label>inhibits lymphocyte proliferation</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000085 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000085">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000016"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mechanism that mediates pathogenicity by modulating the availability or function of immune system components to evade or subvert host immune functions.</obo:IAO_0000115>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">mediates immune evasion and subversion</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000089 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000089">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000164"/>
<obo:IAO_0000115>A mechanism that disrupts cellular metabolism by disrupting the mitochondrial membrane potential.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0033659</oboInOwl:hasDbXref>
<rdfs:label>disrupts mitochondrial membrane potential</rdfs:label>
<skos:editorialNote>For example, during infection Listeria monocytogenes induces a loss of mitochondrial membrane potential by expressing listeriolysin O (LLO) which causes mitochondrial fission. This change leads to reduced ATP production.</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000099 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000099">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000038"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mechanism that enables adhesion by mediating binding to extracellular matrix components such as collagen and fibronectin.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0050840</oboInOwl:hasDbXref>
<rdfs:label>mediates extracellular matrix binding</rdfs:label>
<skos:editorialNote>Mechanism of adherence in which attachment occurs to components of the extracellular matrix as opposed to the target cell directly;
elaborate subclasses
Collagen binding protein and fibronectin binding protein are examples. Including these as subclasses may be too granular.</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000100 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000100">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000085"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mechanism that mediates immune evasion and subversion by countering the effects of the complement system, a component of the innate immune system.</obo:IAO_0000115>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">mediates resistance to complement system</rdfs:label>
<skos:editorialNote>resistance to complement-mediated killing
example:component 1 (C1) protease</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000104 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000104">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000085"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mechanism that mediates immune evasion and subversion by preventing antibacterial peptides from binding to their targets.</obo:IAO_0000115>
<rdfs:label>disrupts antimicrobial peptide binding</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000108 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000108">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000028"/>
<obo:IAO_0000115>A mechanism that modulates cytoskeleton in host cell by mediating inhibition of host actin polymerization.</obo:IAO_0000115>
<rdfs:label>mediates host actin polymerization inhibition</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000110 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000110">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000114"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mechanism that mediates pathogenicity by contributing to secretion of protein effectors from the bacterial cell into the extracellular environment or directly into the host cell.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0044417</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref>GO:0050708</oboInOwl:hasDbXref>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">mediates secretion of protein effectors</rdfs:label>
<skos:editorialNote>elaborate subclasses and align with determinant branch
The secretion pathways are typically described as "types" based on components/structures involved corresponding to variations on a few general strategies involving transport across inner membrane, transport across inner membrane followed by transport across outer membrane (two-step), transport across both membranes. Several types can also transport proteins directly across the host cell membrane to deliver effectors directly into cells
Type I- one step to extracellular
Type II- two step, first step is independent transport into periplasm
Type III- spans both membranes, injectosome into host cell
Type IV- spans both membranes, release of effectors into other cell (conjugation)
Type V-autotransporter in OM, first step is independent transport into periplasm
Type VI- spans both membranes, release into other cell
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804464/
https://www.sciencedirect.com/science/article/pii/S0167488904000783
Evaluate subclass naming/organization</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000113 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000113">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000150"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mechanism that promotes proliferation and survival by contributing to the availability and/or uptake of nutrients from host cells or the environment.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0044002</oboInOwl:hasDbXref>
<rdfs:label>mediates nutrient availability or uptake</rdfs:label>
<skos:editorialNote>evaluate and modify subclasses to achieve consistent structure
examples may include: gelatinase, mucinase, sialidase, hyaluronidase - enzymes that are also associated with destruction of extracellular matrix, mucus, etc. to promote invasion and spread in the host
siderophore-chelate and sequester iron from host</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000114 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000114">
<rdfs:subClassOf rdf:resource="http://www.w3.org/2002/07/owl#Thing"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathogenicity is the ability of microbes to have damaging effects on cells. A mechanism of pathogenicity is a process that pathogens perform to have damaging effects on cells, and that specifically describes how that effect is exerted.</obo:IAO_0000115>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">mechanism of pathogenicity</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000124 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000124">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000058"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mechanism of iron uptake that involves using iron in the environment.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0005506</oboInOwl:hasDbXref>
<rdfs:label>mediates iron acquisition from environment</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000125 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000125">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000150"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mechanism that promotes proliferation and survival by enabling pathogens to survive periods without water, or drought-like conditions.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0009269</oboInOwl:hasDbXref>
<rdfs:label>mediates desiccation resistance</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000132 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000132">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000164"/>
<obo:IAO_0000115>A mechanism that disrupts cellular metabolism by inhibiting DNA synthesis.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:2000279</oboInOwl:hasDbXref>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">inhibits DNA synthesis</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000133 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000133">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000099"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mechanism that mediates extracellular matrix binding by binding to fibronectin.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0001968</oboInOwl:hasDbXref>
<rdfs:label>mediates host fibronectin binding</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000135 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000135">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000113"/>
<obo:IAO_0000115>A mechanism that mediates nutrient availability or uptake by mediating cleavage of host DNA.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0004536</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref>GO:0044003</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref>GO:0052013</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref>GO:1903626</oboInOwl:hasDbXref>
<oboInOwl:hasRelatedSynonym>deoxyribonuclease activity</oboInOwl:hasRelatedSynonym>
<rdfs:label>mediates DNA cleavage</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000142 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000142">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000113"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mechanism that mediates nutrient availability or uptake by taking cholesterol from the membranes of target cells.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0051673</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref>GO:0052006</oboInOwl:hasDbXref>
<rdfs:label>mediates acquisition of cholesterol from membrane</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000147 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000147">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000114"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mechanism that mediates pathogenicity by enabling pathogens to attach to host cells and establish growth.</obo:IAO_0000115>
<oboInOwl:hasDbXref>BVF:0000002</oboInOwl:hasDbXref>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">enables adherence and colonization</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000149 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000149">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000113"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mechanism that mediates nutrient availability or uptake by mediating carbohydrate degradation.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0052015</oboInOwl:hasDbXref>
<rdfs:label>mediates carbohydrate degradation</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000150 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000150">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000114"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mechanism that mediates pathogenicity by allowing pathogens to grow and multiply, especially when environmental conditions are unfavorable, distinct from adherence and colonization.</obo:IAO_0000115>
<rdfs:label>mediates proliferation and survival</rdfs:label>
<skos:editorialNote>evaluate placement and provide examples</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000152 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000152">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000331"/>
<obo:IAO_0000115>A mechanism that modulates the cell cycle of a host cell by inducing cell cycle arrest</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0007050</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref>GO:0044072</oboInOwl:hasDbXref>
<rdfs:label>induces cell cycle arrest</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000154 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000154">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000113"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mechanism of nutrient availability or uptake that involves acquisition of manganese.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0005384</oboInOwl:hasDbXref>
<rdfs:label>mediates manganese uptake</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000159 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000159">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000114"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mechanism that mediates pathogenicity by disrupting the adhesion of cells to other cells and/or extracellular matrix components.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0022408</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref>GO:0044067</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref>GO:0044364</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref>GO:1901889</oboInOwl:hasDbXref>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">disrupts cellular adhesion</rdfs:label>
<skos:editorialNote>evaluate for incorporation to invasion and dissemination
elaborate subclasses</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000161 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000161">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000159"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mechanism that compromises the intestinal mucosal barrier, permitting microbial products and/or microbes entry into the body. The intestinal mucosal barrier consists of the intestinal epithelial layer, plus additional physical, biochemical, and immunological components.</obo:IAO_0000115>
<oboInOwl:hasRelatedSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">gastrointestinal barrier disruption</oboInOwl:hasRelatedSynonym>
<rdfs:label>disrupts mucosal barriers</rdfs:label>
<skos:editorialNote>higher level process, not appropriate subclass; evaluate for removal or alternate placement; revise definition</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000162 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000162">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000159"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mechanism that compromises epithelial cell layers, enabling increased permeation of biomolecules and/or bacterial invasion.</obo:IAO_0000115>
<rdfs:label>disrupts epithelial layers</rdfs:label>
<skos:editorialNote>higher level process, not appropriate subclass; evaluate for removal or alternate placement</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000164 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000164">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000114"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mechanism that mediates pathogenicity by disrupting cellular processes involved in the synthesis or breakdown of cellular constituents or production of energy.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0044068</oboInOwl:hasDbXref>
<rdfs:label>disrupts cellular metabolism</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000165 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000165">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000114"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mechanism that mediates pathogenicity by disrupting host cellular signaling processes.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0044501</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref>GO:0052027</oboInOwl:hasDbXref>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">disrupts host cellular signaling</rdfs:label>
<skos:editorialNote>refine/build out subclasses</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000166 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000166">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000114"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mechanism that mediates pathogenicity by disrupting the structural integrity of a cell.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0052111</oboInOwl:hasDbXref>
<rdfs:label>disrupts cellular structure</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000167 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000167">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000114"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mechanism that mediates pathogenicity by disrupting transport of products into, out of, and within host cells.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0044068</oboInOwl:hasDbXref>
<rdfs:label>disrupts cellular transport</rdfs:label>
<skos:editorialNote>elaborate and restructure subclasses using a consistent organizational principle
example concepts to consider in determining organization:
membrane transport
vesicular transport
endocytosis/exocytosis
active/passive
intracellular trafficking
microtubule mediated transport</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000168 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000168">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000165"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mechanism that disrupts host cell signaling by inhibiting cellular enzymes. For inhibition of metabolic enzymes, see terms under 'disruption of cellular metabolism'.</obo:IAO_0000115>
<rdfs:label>mediates enzyme inhibition</rdfs:label>
<skos:editorialNote>evaluate for placement and provide examples; disambiguate from mediates metabolic enzyme inhibition; revise definition</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000170 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000170">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000164"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mechanism that disrupts cellular metabolism by altering the levels of cyclic adenosine monophosphate (cyclic AMP, or cAMP) in cells. Cyclic AMP is a second messenger molecule that regulates physiological processes in cells, through, for example, activation of intracellular signaling pathways.</obo:IAO_0000115>
<rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">disrupts cellular cAMP levels</rdfs:label>
<skos:editorialNote>redundant to cellular signaling "second messenger disruption"; should be moved; evaluate subclasses</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000171 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000171">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000164"/>
<obo:IAO_0000115>A mechanism that disrupts cellular metabolism by mediating production of reactive oxygen species.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:2000379</oboInOwl:hasDbXref>
<rdfs:label>mediates reactive oxygen species production</rdfs:label>
<skos:editorialNote>should be moved as it is not a logical subclass for 'disrupts cellular metabolism'</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000172 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000172">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000171"/>
<obo:IAO_0000115>A mechanism that mediates reactive oxygen species production by producing nitric oxide radicals, through activation of nitric oxide synthase or otherwise.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0004517</oboInOwl:hasDbXref>
<rdfs:label>produces nitric oxide radicals</rdfs:label>
<skos:editorialNote>Nitric oxide radicals destroy iron-dependent enzymes, eventually inhibiting mitochondrial function and DNA synthesis in host cells.
evaluate placement; not appropriate subclass</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000173 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000173">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000170"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mechanism that disrupts cellular cAMP levels through activation of the production or repression of the breakdown of cAMP.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0051342</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref>GO:0075106</oboInOwl:hasDbXref>
<rdfs:label>modulates cAMP synthesis</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000174 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000174">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000170"/>
<oboInOwl:hasDbXref>GO:0075106</oboInOwl:hasDbXref>
<rdfs:label>regulates host cell adenylate cyclases/phosphodiesterases</rdfs:label>
<skos:editorialNote>evaluate for redundancy with "modulates cAMP synthesis"</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000175 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000175">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000165"/>
<obo:IAO_0000115>A mechanism that disprupts host cell signaling by interfering with host G-protien signaling pathways.</obo:IAO_0000115>
<rdfs:label>disrupts G-protein signaling pathways</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000176 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000176">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000165"/>
<obo:IAO_0000115>A mechanism that disrupts host cellular signaling by modulating receptor activity</obo:IAO_0000115>
<rdfs:label>modulates receptor activity</rdfs:label>
<skos:editorialNote>Vague; Evaluate for removal</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000177 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000177">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000165"/>
<obo:IAO_0000115>A mechanism that disrupts host cellular signaling by modulating levels of second messenger molecules.</obo:IAO_0000115>
<rdfs:label>modulates second messenger molecules</rdfs:label>
<skos:editorialNote>cyclin-dependent kinase 1 inactivator; calcium- and calmodulin-dependent adenylate cyclase</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000211 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000211">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000038"/>
<obo:IAO_0000115>A mechanism that mediates adhesion by enabling binding to cell surface receptors or components.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0044650</oboInOwl:hasDbXref>
<rdfs:label xml:lang="en">mediates cell surface binding</rdfs:label>
<skos:editorialNote>elaborate subclasses
sialyl Lewis x binding protein is an example</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000212 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000212">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000062"/>
<obo:IAO_0000115>A mechanism that enables biofilm formation by contributing to quorum sensing.</obo:IAO_0000115>
<rdfs:label xml:lang="en">mediates quorum sensing</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000213 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000213">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000159"/>
<oboInOwl:hasDbXref>GO:0035893</oboInOwl:hasDbXref>
<rdfs:label xml:lang="en">inhibits platelet aggregation</rdfs:label>
<skos:editorialNote>for example: coagulation factor V protease, or disintegrins
not an appropriate subclass as this is a specific example, evaluate for class related to inhibition of integrin mediated adhesion "disrupts "integrin-dependent adhesion"</skos:editorialNote>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/PATHGO_0000214 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/PATHGO_0000214">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATHGO_0000159"/>
<obo:IAO_0000115>A mechanism that disrupts cellular adhesion by modifying cellular junctional complexes, including tight junctions and/or adherens junctions.</obo:IAO_0000115>
<oboInOwl:hasDbXref>GO:0098864</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref>GO:1903347</oboInOwl:hasDbXref>
<rdfs:label xml:lang="en">modifies host tight or adherens junctions</rdfs:label>
<skos:editorialNote>example: Clostridium perfringens type A toxin (targets claudins) more info: https://doi.org/10.1016/j.bbamem.2008.10.028; https://www.ncbi.nlm.nih.gov/pubmed/11595640
Term changes suggested by Gene Godbold (https://orcid.org/0000-0002-5702-4690)</skos:editorialNote>
</owl:Class>