diff --git a/error.go b/error.go
index 67017c29..70a6b5d6 100644
--- a/error.go
+++ b/error.go
@@ -248,6 +248,43 @@ var NewError = func(status int, msg string, errs ...error) StatusError {
 	}
 }
 
+// HandleTypedError dynamically creates an HTTP error response based on the type of the provided error.
+// This allows API implementers to customize the HTTP error response according to different error types
+// handled by the application.
+//
+// Usage example:
+//
+//	type NotFoundError struct {
+//		Resource string
+//	}
+//
+//	func (e *NotFoundError) Error() string {
+//		return fmt.Sprintf("Resource '%s' not found", e.Resource)
+//	}
+//
+//	type ValidationError struct {
+//		Field   string
+//		Message string
+//	}
+//
+//	func (e *ValidationError) Error() string {
+//		return fmt.Sprintf("Validation failed on '%s': %s", e.Field, e.Message)
+//	}
+//
+//	NewTypedError = func(err error) StatusError {
+//		switch e := err.(type) {
+//		case *NotFoundError:
+//			return NewError(http.StatusNotFound, e.Error())
+//		case *ValidationError:
+//			return NewError(http.StatusBadRequest, e.Error())
+//		default:
+//			return NewError(http.StatusInternalServerError, "An unexpected error has occurred")
+//		}
+//	}
+var HandleTypedError = func(err error) StatusError {
+	return NewError(http.StatusInternalServerError, err.Error())
+}
+
 // WriteErr writes an error response with the given context, using the
 // configured error type and with the given status code and message. It is
 // marshaled using the API's content negotiation methods.
diff --git a/huma.go b/huma.go
index 7cd89e9d..41528fbe 100644
--- a/huma.go
+++ b/huma.go
@@ -1341,7 +1341,7 @@ func Register[I, O any](api API, op Operation, handler func(context.Context, *I)
 				status = se.GetStatus()
 				err = se
 			} else {
-				err = NewError(http.StatusInternalServerError, err.Error())
+				err = HandleTypedError(err)
 			}
 
 			ct, _ := api.Negotiate(ctx.Header("Accept"))
diff --git a/huma_test.go b/huma_test.go
index f61075f7..4f94255e 100644
--- a/huma_test.go
+++ b/huma_test.go
@@ -1940,6 +1940,45 @@ func TestCustomError(t *testing.T) {
 	assert.Equal(t, `{"$schema":"http://localhost/schemas/MyError.json","message":"not found","details":["some-other-error"]}`+"\n", resp.Body.String())
 }
 
+type NotFoundError struct {
+	Resource string
+}
+
+func (e *NotFoundError) Error() string {
+	return fmt.Sprintf("Resource '%s' not found", e.Resource)
+}
+
+func TestTypedError(t *testing.T) {
+	orig := huma.HandleTypedError
+	defer func() {
+		huma.HandleTypedError = orig
+	}()
+
+	huma.HandleTypedError = func(err error) huma.StatusError {
+		switch e := err.(type) {
+		case *NotFoundError:
+			return huma.NewError(http.StatusNotFound, e.Error())
+		default:
+			return huma.NewError(http.StatusInternalServerError, "An unexpected error has occurred")
+		}
+	}
+
+	_, api := humatest.New(t, huma.DefaultConfig("Test API", "1.0.0"))
+
+	huma.Register(api, huma.Operation{
+		OperationID: "get-error",
+		Method:      http.MethodGet,
+		Path:        "/error",
+	}, func(ctx context.Context, i *struct{}) (*struct{}, error) {
+		return nil, &NotFoundError{
+			Resource: "foo",
+		}
+	})
+
+	resp := api.Get("/error", "Host: localhost")
+	assert.Equal(t, `{"$schema":"http://localhost/schemas/ErrorModel.json","title":"Not Found","status":404,"detail":"Resource 'foo' not found"}`+"\n", resp.Body.String())
+}
+
 type NestedResolversStruct struct {
 	Field2 string `json:"field2"`
 }