diff --git a/src/cdk-experimental/ui-patterns/behaviors/list-typeahead/list-typeahead.spec.ts b/src/cdk-experimental/ui-patterns/behaviors/list-typeahead/list-typeahead.spec.ts
index 1be9ab8d0745..4f82a8f15027 100644
--- a/src/cdk-experimental/ui-patterns/behaviors/list-typeahead/list-typeahead.spec.ts
+++ b/src/cdk-experimental/ui-patterns/behaviors/list-typeahead/list-typeahead.spec.ts
@@ -27,117 +27,65 @@ describe('List Typeahead', () => {
     );
   }
 
+  let items: SignalLike<TestItem[]>;
+  let typeahead: ListTypeahead<TestItem>;
+  let navigation: ListNavigation<TestItem>;
+
+  beforeEach(() => {
+    items = getItems(5);
+    navigation = new ListNavigation({
+      items,
+      wrap: signal(false),
+      activeIndex: signal(0),
+      skipDisabled: signal(false),
+      textDirection: signal('ltr'),
+      orientation: signal('vertical'),
+    });
+    typeahead = new ListTypeahead({
+      navigation,
+      typeaheadDelay: signal(0.5),
+    });
+  });
+
   describe('#search', () => {
     it('should navigate to an item', () => {
-      const items = getItems(5);
-      const activeIndex = signal(0);
-      const navigation = new ListNavigation({
-        items,
-        activeIndex,
-        wrap: signal(false),
-        skipDisabled: signal(false),
-        textDirection: signal('ltr'),
-        orientation: signal('vertical'),
-      });
-      const typeahead = new ListTypeahead({
-        navigation,
-        typeaheadDelay: signal(0.5),
-      });
-
       typeahead.search('i');
-      expect(activeIndex()).toBe(1);
+      expect(navigation.inputs.activeIndex()).toBe(1);
 
       typeahead.search('t');
       typeahead.search('e');
       typeahead.search('m');
       typeahead.search(' ');
       typeahead.search('3');
-      expect(activeIndex()).toBe(3);
+      expect(navigation.inputs.activeIndex()).toBe(3);
     });
 
     it('should reset after a delay', fakeAsync(() => {
-      const items = getItems(5);
-      const activeIndex = signal(0);
-      const navigation = new ListNavigation({
-        items,
-        activeIndex,
-        wrap: signal(false),
-        skipDisabled: signal(false),
-        textDirection: signal('ltr'),
-        orientation: signal('vertical'),
-      });
-      const typeahead = new ListTypeahead({
-        navigation,
-        typeaheadDelay: signal(0.5),
-      });
-
       typeahead.search('i');
-      expect(activeIndex()).toBe(1);
+      expect(navigation.inputs.activeIndex()).toBe(1);
 
       tick(500);
 
       typeahead.search('i');
-      expect(activeIndex()).toBe(2);
+      expect(navigation.inputs.activeIndex()).toBe(2);
     }));
 
     it('should skip disabled items', () => {
-      const items = getItems(5);
-      const activeIndex = signal(0);
-      const navigation = new ListNavigation({
-        items,
-        activeIndex,
-        wrap: signal(false),
-        skipDisabled: signal(true),
-        textDirection: signal('ltr'),
-        orientation: signal('vertical'),
-      });
-      const typeahead = new ListTypeahead({
-        navigation,
-        typeaheadDelay: signal(0.5),
-      });
       items()[1].disabled.set(true);
-
+      (navigation.inputs.skipDisabled as WritableSignalLike<boolean>).set(true);
       typeahead.search('i');
-      expect(activeIndex()).toBe(2);
+      console.log(typeahead.inputs.navigation.inputs.items().map(i => i.disabled()));
+      expect(navigation.inputs.activeIndex()).toBe(2);
     });
 
     it('should not skip disabled items', () => {
-      const items = getItems(5);
-      const activeIndex = signal(0);
-      const navigation = new ListNavigation({
-        items,
-        activeIndex,
-        wrap: signal(false),
-        skipDisabled: signal(false),
-        textDirection: signal('ltr'),
-        orientation: signal('vertical'),
-      });
-      const typeahead = new ListTypeahead({
-        navigation,
-        typeaheadDelay: signal(0.5),
-      });
       items()[1].disabled.set(true);
-
+      (navigation.inputs.skipDisabled as WritableSignalLike<boolean>).set(false);
       typeahead.search('i');
-      expect(activeIndex()).toBe(1);
+      expect(navigation.inputs.activeIndex()).toBe(1);
     });
 
     it('should ignore keys like shift', () => {
-      const items = getItems(5);
-      const activeIndex = signal(0);
-      const navigation = new ListNavigation({
-        items,
-        activeIndex,
-        wrap: signal(false),
-        skipDisabled: signal(false),
-        textDirection: signal('ltr'),
-        orientation: signal('vertical'),
-      });
-      const typeahead = new ListTypeahead({
-        navigation,
-        typeaheadDelay: signal(0.5),
-      });
-
       typeahead.search('i');
       typeahead.search('t');
       typeahead.search('e');
@@ -147,7 +95,18 @@ describe('List Typeahead', () => {
       typeahead.search('m');
       typeahead.search(' ');
       typeahead.search('2');
-      expect(activeIndex()).toBe(2);
+      expect(navigation.inputs.activeIndex()).toBe(2);
+    });
+
+    it('should not allow a query to begin with a space', () => {
+      typeahead.search(' ');
+      typeahead.search('i');
+      typeahead.search('t');
+      typeahead.search('e');
+      typeahead.search('m');
+      typeahead.search(' ');
+      typeahead.search('3');
+      expect(navigation.inputs.activeIndex()).toBe(3);
     });
   });
 });
diff --git a/src/cdk-experimental/ui-patterns/behaviors/list-typeahead/list-typeahead.ts b/src/cdk-experimental/ui-patterns/behaviors/list-typeahead/list-typeahead.ts
index aaa2350d6d63..36d3a65898b3 100644
--- a/src/cdk-experimental/ui-patterns/behaviors/list-typeahead/list-typeahead.ts
+++ b/src/cdk-experimental/ui-patterns/behaviors/list-typeahead/list-typeahead.ts
@@ -6,7 +6,7 @@
  * found in the LICENSE file at https://angular.dev/license
  */
 
-import {signal} from '@angular/core';
+import {computed, signal} from '@angular/core';
 import {SignalLike} from '../signal-like/signal-like';
 import {ListNavigationItem, ListNavigation} from '../list-navigation/list-navigation';
 
@@ -36,6 +36,9 @@ export class ListTypeahead<T extends ListTypeaheadItem> {
   /** The navigation controller of the parent list. */
   navigation: ListNavigation<T>;
 
+  /** Whether the user is actively typing a typeahead search query. */
+  isTyping = computed(() => this._query().length > 0);
+
   /** Keeps track of the characters that typeahead search is being called with. */
   private _query = signal('');
 
@@ -52,6 +55,10 @@ export class ListTypeahead<T extends ListTypeaheadItem> {
       return;
     }
 
+    if (!this.isTyping() && char === ' ') {
+      return;
+    }
+
     if (this._startIndex() === undefined) {
       this._startIndex.set(this.navigation.inputs.activeIndex());
     }
diff --git a/src/cdk-experimental/ui-patterns/listbox/listbox.ts b/src/cdk-experimental/ui-patterns/listbox/listbox.ts
index bba0f2444ba6..1e9425248980 100644
--- a/src/cdk-experimental/ui-patterns/listbox/listbox.ts
+++ b/src/cdk-experimental/ui-patterns/listbox/listbox.ts
@@ -91,6 +91,9 @@ export class ListboxPattern<V> {
     return this.inputs.textDirection() === 'rtl' ? 'ArrowLeft' : 'ArrowRight';
   });
 
+  /** Represents the space key. Does nothing when the user is actively using typeahead. */
+  dynamicSpaceKey = computed(() => (this.typeahead.isTyping() ? '' : ' '));
+
   /** The regexp used to decide if a key should trigger typeahead. */
   typeaheadRegexp = /^.$/; // TODO: Ignore spaces?
 
@@ -127,22 +130,24 @@ export class ListboxPattern<V> {
 
     if (this.inputs.multi()) {
       manager
-        .on(Modifier.Shift, ' ', () => this._updateSelection({selectFromAnchor: true}))
         .on(Modifier.Shift, 'Enter', () => this._updateSelection({selectFromAnchor: true}))
         .on(Modifier.Shift, this.prevKey, () => this.prev({toggle: true}))
         .on(Modifier.Shift, this.nextKey, () => this.next({toggle: true}))
         .on(Modifier.Ctrl | Modifier.Shift, 'Home', () => this.first({selectFromActive: true}))
         .on(Modifier.Ctrl | Modifier.Shift, 'End', () => this.last({selectFromActive: true}))
-        .on(Modifier.Ctrl, 'A', () => this._updateSelection({selectAll: true}));
+        .on(Modifier.Ctrl, 'A', () => this._updateSelection({selectAll: true}))
+        .on(Modifier.Shift, this.dynamicSpaceKey, () =>
+          this._updateSelection({selectFromAnchor: true}),
+        );
     }
 
     if (!this.followFocus() && this.inputs.multi()) {
-      manager.on(' ', () => this._updateSelection({toggle: true}));
+      manager.on(this.dynamicSpaceKey, () => this._updateSelection({toggle: true}));
       manager.on('Enter', () => this._updateSelection({toggle: true}));
     }
 
     if (!this.followFocus() && !this.inputs.multi()) {
-      manager.on(' ', () => this._updateSelection({toggleOne: true}));
+      manager.on(this.dynamicSpaceKey, () => this._updateSelection({toggleOne: true}));
       manager.on('Enter', () => this._updateSelection({toggleOne: true}));
     }