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quinoxaline-xk469-cqs.bib
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%% This BibTeX bibliography file was created using BibDesk.
%% https://bibdesk.sourceforge.io/
%% Created for Vincent Montero at 2022-10-10 16:40:22 -0400
%% Saved with string encoding Unicode (UTF-8)
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Jennifer Czarnecki and Lance Heilbrun and Jerome P. Horwitz
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author = {Zhenhua Ding and Jun-Ying Zhou and Wei-Zen Wei and Vicki V
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title = {Induction of Apoptosis By the New Anticancer Drug Xk469 in
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@article{gao-2003-dna-sequen,
author = {Hanlin Gao and Edith F. Yamasaki and Kenneth K. Chan and
Linus L. Shen and Robert M. Snapka},
title = {Dna Sequence Specificity for Topoisomerase Ii Poisoning By
the Quinoxaline Anticancer Drugs Xk469 and Cqs},
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}
@article{hazeldine-2001-desig-synth,
author = {Stuart T. Hazeldine and Lisa Polin and Juiwanna Kushner and
Jennifer Paluch and Kathryn White and Matthew Edelstein and
Eduardo Palomino and Thomas H. Corbett and Jerome P. Horwitz},
title = {Design, Synthesis, and Biological Evaluation of Analogues
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2-{4-[(7-Chloro-2-quinoxalinyl)oxy]phenoxy}propionic Acid
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@article{hazeldine-2002-ii,
author = {Stuart T. Hazeldine and Lisa Polin and Juiwanna Kushner and
Kathryn White and Nicole M. Bouregeois and Brianna Crantz and
Eduardo Palomino and Thomas H. Corbett and Jerome P. Horwitz},
title = {Ii. Synthesis and Biological Evaluation of Some
Bioisosteres and Congeners of the Antitumor Agent,
2-{4-[(7-Chloro-2-quinoxalinyl)oxy]phenoxy}propionic Acid
(XK469)},
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}
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author = {Stuart T. Hazeldine and Lisa Polin and Juiwanna Kushner and
Kathryn White and Thomas H. Corbett and Jason Biehl and Jerome
P. Horwitz},
title = {Part 3: Synthesis and Biological Evaluation of Some Analogs
of the Antitumor Agents,
2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic Acid, and
2-{4-[(7-bromo-2-quinolinyl)oxy]phenoxy}propionic Acid},
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}
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Kathryn White and Thomas H. Corbett and Jerome P. Horwitz},
title = {Synthetic Modification of the 2-oxypropionic Acid Moiety in
2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic Acid
(XK469), and Consequent Antitumor Effects. Part 4},
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}
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author = {Stuart T. Hazeldine and Lisa Polin and Juiwanna Kushner and
Kathryn White and Thomas H. Corbett and Jerome P. Horwitz},
title = {Synthesis and Biological Evaluation of Conformationally
Constrained Analogs of the Antitumor Agents Xk469 and Sh80.
Part 5},
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}
@article{he-2006-solub-two,
author = {Yan He and S.Esmail Tabibi and Samuel H. Yalkowsky},
title = {Solubilization of Two Structurally Related Anticancer
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author = {J. Matthew Hutzler and Young-Sun Yang and Daniel Albaugh
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Cryopreserved Human Hepatocytes},
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author = {Nisha C. Kakodkar and Radhika Peddinti and Morris Kletzel
and Yufeng Tian and Lisa J. Guerrero and Samir D. Undevia and
David Geary and Alexandre Chlenski and Qiwei Yang and Helen R.
Salwen and Susan L. Cohn},
title = {The Quinoxaline Anti-Tumor Agent (R+)XK469 Inhibits
Neuroblastoma Tumor Growth},
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}
@article{kessel-2001-pro-apopt,
author = {David Kessel and Jerome P. Horwitz},
title = {Pro-Apoptotic Interactions Between Xk469 and the Peripheral
Benzodiazepine Receptor},
journal = {Cancer Letters},
volume = 168,
number = 2,
pages = {141-144},
year = 2001,
doi = {10.1016/s0304-3835(01)00518-3},
url = {http://dx.doi.org/10.1016/s0304-3835(01)00518-3},
DATE_ADDED = {Wed Mar 29 14:46:21 2023},
}
@article{kessel-2007-role-autop,
author = {David Kessel and John J. Reiners and Stuart T. Hazeldine
and Lisa Polin and Jerome P. Horwitz},
title = {The Role of Autophagy in the Death of L1210 Leukemia Cells
Initiated By the New Antitumor Agents, Xk469 and Sh80},
journal = {Molecular Cancer Therapeutics},
volume = 6,
number = 1,
pages = {370-379},
year = 2007,
doi = {10.1158/1535-7163.mct-05-0386},
url = {http://dx.doi.org/10.1158/1535-7163.MCT-05-0386},
DATE_ADDED = {Wed Mar 29 14:39:56 2023},
}
@article{lin-2001-mitot-arres,
author = {Hong Lin and Xiang Y. Liu and Balanehru Subramanian and
Alexander Nakeff and Fred Valeriote and Ben D. Chen},
title = {Mitotic Arrest Induced By Xk469, a Novel Antitumor Agent,
Is Correlated With the Inhibition of Cyclin B1 Ubiquitination},
journal = {International Journal of Cancer},
volume = 97,
number = 1,
pages = {121-128},
year = 2001,
doi = {10.1002/ijc.1570},
url = {http://dx.doi.org/10.1002/ijc.1570},
DATE_ADDED = {Wed Mar 29 14:45:44 2023},
}
@article{lin-2002-xk469-novel,
author = {Hong Lin and Balanehru Subramanian and Alex Nakeff and Ben
Chen},
title = {Xk469, a Novel Antitumor Agent, Inhibits Signaling By the
Mek/mapk Signaling Pathway},
journal = {Cancer Chemotherapy and Pharmacology},
volume = 49,
number = 4,
pages = {281-286},
year = 2002,
doi = {10.1007/s00280-002-0425-7},
url = {http://dx.doi.org/10.1007/s00280-002-0425-7},
DATE_ADDED = {Wed Mar 29 14:45:07 2023},
}
@article{lorusso-1998-precl-antit,
author = {Patricia M LoRusso and Ralph Parchment and Lisa Demchik and
Juianna Knight and Lisa Polin and Janet Dzubow and Carl
Behrens and Barbara Harrison and George Trainor and Thomas H.
Corbett},
title = {Preclinical Antitumor Activity of Xk469 (NSC 656889)},
journal = {Investigational New Drugs},
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author = {Gao, Hanlin and Yamasaki, Edith F. and Chan, Kenneth K. and Shen, Linus L. and Snapka, Robert M.},
title = "{Chloroquinoxaline Sulfonamide (NSC 339004) Is a Topoisomerase IIα/β Poison1}",
journal = {Cancer Research},
volume = {60},
number = {21},
pages = {5937-5940},
year = {2000},
month = {11},
abstract = "{Chloroquinoxaline sulfonamide (chlorosulfaquinoxaline, CQS, NSC 339004)is active against murine and human solid tumors. On the basis of its structural similarity to the topoisomerase IIβ-specific drug XK469,CQS was tested and found to be both a topoisomerase-IIα and a topoisomerase-IIβ poison. Topoisomerase II poisoning by CQS is essentially undetectable in assays using the common protein denaturant SDS, but easily detectable with strong chaotropic protein denaturants. The finding that detection of topoisomerase poisoning can be so dependent on the protein denaturant used in the assay has implications for drug discovery efforts and for our understanding of topoisomerase poisons.}",
issn = {0008-5472},
eprint = {https://aacrjournals.org/cancerres/article-pdf/60/21/5937/3249624/ch210005937p.pdf},
}
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title = {Dna Sequence Specificity for Topoisomerase Ii Poisoning By
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Human Cell Lines Derived From Non-Seminomatous Germ Cell
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author = {Vincent A. Miller and James R. Rigas and William P. Tong
and Janice R. Reid and Katherine M. W. Pisters and Stefan C.
Grant and Robert T. Heelan and Mark G. Kris},
title = {Phase Ii Trial of Chloroquinoxaline Sulfonamide (CQS) in
Patients With Stage Iii and Iv Non-Small-Cell Lung Cancer},
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@article{rigas-1992-clin-trial,
author = {Rigas, James R. and Tong, William P. and Kris, Mark G. and Orazem, John P. and Young, Charles W. and Warrell, Raymond P., Jr.},
title = "{Phase I Clinical and Pharmacological Study of Chloroquinoxaline Sulfonamide1}",
journal = {Cancer Research},
volume = {52},
number = {23},
pages = {6619-6623},
year = {1992},
month = {12},
abstract = "{Chloroquinoxaline sulfonamide (CQS) is a halogenated heterocyclic sulfanilamide identified by the in vitro human tumor colony-forming assay as an active agent in a variety of human solid tumors. In this phase I study, 182 courses of CQS were administered intravenously every 28 days to 88 patients at doses ranging from 18 to 4870 mg/m2. Hypoglycemia associated with hyperinsulinemia was the dose-limiting adverse effect at 4870 mg/m2. Supraventricular tachyarrhythmias were observed at doses \\>4000 mg/m2. Less common reactions included infusion site phlebitis, nausea, anemia, alopecia, perioral numbness, and diarrhea. Cumulative toxicity was not observed. Minor objective antitumor responses were noted in 7 patients; 6 of the 7 responses occurred in patients with non-small cell lung cancer.Results of pharmacokinetic studies were consistent with the preclinical observations that CQS is highly bound to plasma protein. Plasma elimination followed a two-compartment model; the mean t½a was 2.7 ± 0.3 h and the t½β was 52 ± 6 h (± SE). The total body clearance and the volume of distribution at steady state of CQS both increased with the dose (distribution at steady state, 3.7–10.5 liter/m2; total body clearance, 53–264 ml/h/m2 for doses of 18–4060 mg/m2) and may reflect saturation of the protein binding and “free” drug clearance.Although inactive against common animal tumors in preclinical screening systems both in vitro and in vivo, CQS has demonstrated definite activity in the human tumor stem cell colony-forming assays, as well as modest anticancer activity in this phase I study in patients with advanced solid tumors. The pharmacokinetic results and the limiting effect of transient hypoglycemia suggest that considerably higher cumulative doses of CQS could be administered using a more frequent dosing schedule.The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.}",
issn = {0008-5472},
eprint = {https://aacrjournals.org/cancerres/article-pdf/52/23/6619/2448950/crs0520236619.pdf},
}
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title = {Clinical and Pharmacology Study of Chloroquinoxaline
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DATE_ADDED = {Wed Mar 29 15:44:45 2023},
}
@article{solar-2013-expan-synth,
author = {Virginia del Solar and Adolfo Qui{\~n}ones-Lombra{\~n}a and
Silvia Cabrera and Jos{\'e} M. Padr{\'o}n and Carla
R{\'i}os-Luci and Amparo Alvarez-Vald{\'e}s and Carmen